Equality and Better Treatment Sought for Lung Cancer Patients

http://www.dailynews.com/lalife/ci_12680005

An excerpt from the article:

Weitz, who is one of the 215,000 people diagnosed each year with lung cancer, knows what others think: "You did it to yourself," the Woodland Hills man said.

But Weitz never smoked cigarettes - did nothing he knows of that would infect the delicate tissue of his lungs.

Yet even for those with lung cancer who have never smoked, the condition comes with a negative stereotype. They often are asked, "Did you smoke?"

It's a perception health advocates say needs to be shattered. Why, they ask, should state or federal funding toward the detection and treatment of lung cancer be any different than, say, for illnesses associated with obesity, alcoholism or other kinds of cancer?

"We have to get to the point of saying it doesn't matter," said Kim Norris, a Los Angeles resident who founded the Lung Cancer Foundation of America.

The foundation's goal is to raise enough funds to lead to lung cancer research and treatment. The five-year survival rates for all stages of lung cancer haven't changed in decades, a result of little progress toward finding better treatments, Norris said.

Norris and others note that research for lung cancer treatment remains "under-funded, under-researched and under-reported," because government funders view it as the "the black sheep" of cancers.

"Just because smoking is legal - and the Department of Defense once handed out cigarettes during wars - doesn't mean (those who smoked) deserve (lung cancer)."

Does Lung Cancer Get Short Shrift?

An excerpt:

Lung cancer kills almost 162,000 Americans each year, more than any other type of malignancy, and yet it gets less research funding per death than any other major cancer. Breast cancer, which gets far more attention, kills about 30,000 fewer women per year than lung cancer does.

And the fastest growing group of lung cancer patients are women like Ms. Alfano, who never smoked.

Read more: http://www.post-gazette.com/pg/09172/978938-114.stm?cmpid=relatedarticle#ixzz0NGtcC2La

http://www.post-gazette.com/pg/09172/978938-114.stm?cmpid=relatedarticle

Audio clip from NPR: Non-Smokers Suffer Lung Cancer Stigma

Great 4 minute clip:

"Smoking is such a well-known cause of lung cancer that many don't realize thousands who never smoked get the diagnosis. The great majority are women. Recent research shows it's really a different disease than smoking-related lung cancer. But those with the diagnosis say they suffer the same stigma."

Listen here: http://www.npr.org/templates/story/story.php?storyId=106033956&ft=1&f=3

Thank you to Andrea for sending this over!

Lung Cancer Alliance--powerful message

This is an incredibly impactful message. These people are all awesome. Lung Cancer Alliance (http://www.lungcanceralliance.org/) is a national organization. Georgia has a great chapter.

Free to Breathe - November 7th

Join Team Haney in the National Walk event for Free to Breathe on November 7th, 2009!

Check on our status, donate, or join our group here: http://participate.freetobreathe.org/goto/teamhaney

You can also join an event near you. Follow the link below for more details:
http://www.freetobreathe.com

Lung Cancer in American Women: Facts

From the National Lung Cancer Partnership:

• Of the over 215,000 cases of lung cancer diagnosed in the U.S. each year, more than 100,300 (47%) are in women. Over 71,000 women die from lung cancer annually, accounting for 26 percent of cancer deaths among women. ¹



• One in 16 women will develop lung cancer in her lifetime.¹



• Lung cancer is the leading cancer killer of women in the U.S. ¹



• Lung cancer kills 30,000 more women than breast cancer annually in the U.S. ¹



• Lung cancer takes the lives of more women each year than breast, ovarian and uterine cancers combined. ¹



• The five year survival rate for lung cancer is only 16 percent compared to an 89 percent five year survival rate for breast cancer. ^{1, 2}



• 1 in 5 women with lung cancer has never smoked (in men with lung cancer, only 1 in 10 has never smoked).1 Women who have never smoked may be more at risk for lung cancer than men who have never smoked.³



• Of the approximately 20,000-25,000 never-smokers diagnosed with lung cancer in the U.S. each year, more than 60 percent of them are women. ⁴



• Of the approximately 3,400 people who die from lung cancer in the U.S. annually due to exposure from second-hand smoke, 2,200 (65%) of them are women. ⁵




• Some evidence suggests that women may be more sensitive than men to the cancer-causing effects of chemicals in cigarettes.^6-12




• Approximately 9 percent of women diagnosed with lung cancer are younger then 50 years old, compared to 7 percent of men with lung cancer. ¹³




• Women are more likely than men to get a sub-type of lung cancer called bronchioloalveolar carcinoma (BAC).13 The incidence of BAC appears to be rising worldwide. ^15-17



• Women typically fare better than men after treatment for lung cancer. ^{13, 18-22}



• Women with lung cancer are more likely than their male counterparts to have specific genetic mutations.9, 23-28 These mutations may be involved in lung cancer risk.



• Research indicates that the female hormone estrogen may be involved in lung cancer risk in women. ^29-32



• Lung cancer research is significantly under-funded. In 2007, the National Cancer Institute spent approximately $1,415 per lung cancer death, compared to $13,991 per breast cancer death, $10,945 per prostate cancer death, and $4,952 per colorectal cancer death. ^33-34


How Can I Reduce My Risk?


• If you smoke, get the help you need to quit (state quitlines can be accessed at http://www.naquitline.org/ or by calling 1-800-QUIT-NOW).




• If you live in an area with high levels of radon coming from the bedrock (see http://www.epa.gov/radon/ ), consider having your house tested for radon exposure. If radon levels are too high, a device can be installed to reduce them.




• Eat a well-balanced diet and exercise. These activities help reduce the risk of all cancers.



• If you smoke now or smoked in the past, or have a family history of lung cancer, consider speaking to your doctor about screening tests that may be available to you. Cancer is most treatable when it is detected early.


References Cited

1. American Cancer Society. Cancer Facts and Figures 2008. Atlanta: American Cancer Society; 2008.
2. American Cancer Society, Breast Cancer Facts & Figures 2005-2006. Atlanta: American Cancer Society, Inc.
3. Wakelee, H.A., et al., Lung Cancer Incidence in Never Smokers. J Clin Oncol, 2007. 25(5): p. 472-8.
4. MMWR Morb Mortal Wkly Rep. 2005. 54(25):625-628
5. California Environmental Protection Agency. Proposed identification of environmental tobacco smoke as a toxic air contaminant-June 2005. California Environmental Protection Agency, California Air Resources Board, Office of Environmental Health Hazard Assessment; 2005.
6. International Early Lung Cancer Action Program Investigators, Women’s susceptibility to tobacco carcinogens and survival after diagnosis of lung cancer. JAMA, 2006. 296(2): p. 180-84.
7. Henschke, C.I. and O.S. Miettinen, Women's susceptibility to tobacco carcinogens. Lung Cancer, 2004. 43(1): p. 1-5.
8. Nordlund, L.A., J.M. Carstensen, and G. Pershagen, Are male and female smokers at equal risk of smoking-related cancer: evidence from a Swedish prospective study. Scand J Public Health, 1999. 27(1): p. 56-62.
9. Tang, D.L., et al., Associations between both genetic and environmental biomarkers and lung cancer: evidence of a greater risk of lung cancer in women smokers. Carcinogenesis, 1998. 19(11): p. 1949-53.
10. Zang, E.A. and E.L. Wynder, Differences in lung cancer risk between men and women: examination of the evidence. J Natl Cancer Inst, 1996. 88(3-4): p. 183-92.
11. Risch, H.A., et al., Are female smokers at higher risk for lung cancer than male smokers? A case-control analysis by histologic type. Am J Epidemiol, 1993. 138(5): p. 281-93.
12. Harris, R.E., et al., Race and sex differences in lung cancer risk associated with cigarette smoking. Int J Epidemiol, 1993. 22(4): p. 592-9.
13. Fu, J.B., et al., Lung cancer in women: analysis of the national Surveillance, Epidemiology, and End Results database. Chest, 2005. 127(3): p. 768-77.
14. Moore, R., et al., Sex differences in survival in non-small cell lung cancer patients 1974-1998. Acta Oncol, 2004. 43(1): p. 57-64.
15. Jackman, D.M., L.R. Chirieac, and P.A. Janne, Bronchioloalveolar carcinoma: a review of the epidemiology, pathology, and treatment. Semin Respir Crit Care Med, 2005. 26(3): p. 342-52.
16. Furak., J., et al., Bronchioloalveolar lung cancer: occurrence, surgical treatment and survival. Eur J Cardiothorac Surg, 2003. 23(5): p. 818-23.
17. Barsky, S.H., et al., Rising incidence of bronchioloalveolar lung carcinoma and its unique clinicopathologic features. Cancer, 1994. 73(4): p. 163-70.
18. Kris, M.G., et al., Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. Jama, 2003. 290(16): p. 2149-58.
19. Fukuoka, M., et al., Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol, 2003. 21(12): p. 2237-46.
20. Alexiou, C., et al., Do women live longer following lung resection for carcinoma? Eur J Cardiothorac Surg, 2002. 21(2): p. 319-25.
21. de Perrot, M., et al., Sex differences in presentation, management, and prognosis of patients with non-small cell lung carcinoma. J Thorac Cardiovasc Surg, 2000. 119(1): p. 21-6.
22. Albain, K.S., J.J. Crowley, M. LeBlanc, and R.B. Livingston. Determinants of improved outcome in small-cell lung cancer: an analysis of the 2,580-patient Southwest Oncology Group database. J Clin Oncol. 1990. 8(9): p. 1563-74.
23. Toyooka, S., T. Tsuda, and A.F. Gazdar, The TP53 gene, tobacco exposure, and lung cancer. Hum Mutat, 2003. 21(3): p. 229-39.
24. Mollerup, S., et al., Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients. Cancer Res, 1999. 59(14): p. 3317-20.
25. Nelson, H.H., et al., Implications and prognostic value of K-ras mutation for early-stage lung cancer in women. J Natl Cancer Inst, 1999. 91(23): p. 2032-8.
26. Kure, E.H., et al., p53 mutations in lung tumours: relationship to gender and lung DNA adduct levels. Carcinogenesis, 1996. 17(10): p. 2201-5.
27. Dresler, C.M., et al., Gender differences in genetic susceptibility for lung cancer. Lung Cancer, 2000. 30(3): p. 153-60.
28. Ryberg, D., et al., Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients. Cancer Res, 1994. 54(22): p. 5801-3.
29. Stabile L.P. and J.M. Estrogen receptor pathways in lung cancer. Curr Oncol Rep. 2004 6(4): p. 259-67.
30. Stabile, L.P., et al., Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen. Cancer Res, 2002. 62(7): p. 2141-50.
31. Fasco, M.J., G.J. Hurteau, and S.D. Spivack, Gender-dependent expression of alpha and beta estrogen receptors in human nontumor and tumor lung tissue. Mol Cell Endocrinol, 2002. 188(1-2): p. 125-40.
32. Mooney, L.A., et al., Gender differences in autoantibodies to oxidative DNA base damage in cigarette smokers. Cancer Epidemiol Biomarkers Prev, 2001. 10(6): p. 641-8.
33. American Cancer Society, Cancer Facts & Figures 2007. Atlanta: American Cancer Society; 2007.
34. National Cancer Institute snapshots: http://planning.cancer.gov/disease/snapshots.shtml


Please refer to our site for more detailed information.

Father loses battle with lung cancer

John Atkinson, father of three young children, advocate and inspiration to many recently lost his battle with lung cancer.

Visit msnbc.com for Breaking News, World News, and News about the Economy

Lung Cancer in Never-Smokers--Unique Characteristics

See video linked below for a science-based look at how lung cancer differs as a disease between never-smokers and those who smoked. These distinctions help to understand lung cancer as a disease for both sub-populations, not to serve as a basis for further blame or suggest that one group is less deserving than another.

http://cancergrace.org/lung/2009/05/21/vodcast-never-smoker-lc/

Lung Cancer in the United States: Facts

From the National Lung Cancer Partnership:

* Approximately 219,000 people are diagnosed with lung cancer in the U.S. each year – over 103,000 women and nearly 116,000 men.

* Lung cancer kills more than 160,000 people annually – more people than breast, colon and prostate cancers combined.

* Lung cancer is responsible for more than 28% of all cancer-related deaths every year.

*Smoking is the primary cause of lung cancer. Approximately 87 percent of lung cancer cases occur in people who are currently smoking or have previously smoked.

*Although the risk of developing lung cancer goes down with smoking cessation, a significant risk remains for 20 years or longer after quitting.

*Approximately 50 percent of all lung cancers (106,500) occur in people who have already quit smoking.

* Radon exposure is the second leading cause of lung cancer, and the leading cause of lung cancer among never-smokers.

*More people who have never smoked die from lung cancer than do people from AIDS or liver cancer or ovarian cancer.

* Risk factors for lung cancer other than those from smoking include lung scarring from tuberculosis, and occupational or environmental exposures to radon, second-hand smoke, radiation, asbestos, air pollution, arsenic and some organic chemicals.

* Only 16 percent of lung cancer patients are diagnosed before their disease has spread to other parts of their bodies, (e.g., regional lymph nodes and beyond), compared to more than 50 percent of breast cancer patients, and 90 percent of prostate cancer patients.

* Men’s mortality (death) rates from lung cancer began declining more than 20 years ago, while women’s lung cancer mortality rates have been rising for decades and just recently began to stabilize.9

* African Americans experience the highest incidence of lung cancer, and the highest death rate.10

* Roughly 84 percent of people diagnosed with lung cancer die within five years of their diagnosis, compared to 11 percent of breast cancer and less than 1 percent of prostate cancer patients.1

* Less money is spent on lung cancer research than on research on other cancers. In 2007, the National Cancer Institute estimated it spent only it spent only $1,415 per lung cancer death compared to $13,991 per breast cancer death, $10,945 per prostate cancer death, and $4,952 per colorectal cancer.1, 11

How Can I Reduce My Risk?

* If you smoke, get the help you need to quit (state quitlines can be accessed at www.naquitline.org or by calling 1-800-QUIT-NOW).

* If you live in an area with high levels of radon coming from the bedrock (see www.epa.gov/radon), consider having your house tested for radon exposure. If radon levels are too high, a device can be installed to reduce them.

*Eat a well-balanced diet and exercise. These activities help reduce the risk of all cancers.

* If you smoke now or smoked in the past, or have a family history of lung cancer, consider speaking to your doctor about screening tests that may be available to you. Cancer is most treatable when it is detected early.

References Cited

1. American Cancer Society. Cancer Facts and Figures 2009. Atlanta: American Cancer Society; 2009.
2. Satcher, D., T.G. Thompson and J.P. Kaplan, Women and smoking: a report of the Surgeon General. Nicotine Tob Res, 2002. 4(1): p. 7-20.
3. Ebbert, J.O., et al., Lung cancer risk reduction after smoking cessation: observations from a prospective cohort of women. J Clin Oncol, 2003. 21(5): p. 921-6.
4. Tong, L., M.R. Spitz, J.J. Fueger, and C.A. Amos, Lung carcinoma in former smokers. Cancer, 1996. 78(5): p. 1004-10.
5. National Research Council, Health Effects of Exposure to Radon: BEIR V. National Academy Press, Washington, DC, 1999.
6. MMWR Morb Mortal Wkly Rep. 2005; 54(25):625-628
7. Hoyert, D.L., M.P. Heron, S.L. Murphy, H. Kung. Deaths: Final Data for 2003. National vital statistics reports; 54(13). Hyattsville, MD: National Center for Health Statistics. 2006.
8. American Cancer Society, Breast Cancer Facts & Figures 2005-2006. Atlanta: American Cancer Society, Inc.
9. Jemal, A., R.C. Tiwari, T. Murray, A. Ghafoor, A. Samuels, E. Ward, E.J. Feuer, and M.J. Thun, Cancer statistics, 2004. CA Cancer J Clin, 2004. 54(1): p. 8-29.
10. Centers for disease Control and Prevention, Health, United States, 2006 National Center for Health Statistics: Atlanta, GA. p. 180, 244.
11. National Cancer Institute Snapshots: http://planning.cancer.gov/disease/snapshots.shtml

Last updated 06/09/09

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Kaleidoscope and Olivia Newton John

Lung cancer is finally considered a women's cancer... Yeah! (Good thing, since it is the biggest cancer killer of women, by far, killing almost twice as many women as breast cancer.) We've been overlooked for a long time...perhaps a shift in thinking is (slowly) on its way!

See folks from ASCO and Olivia Newton-John highlight the new Kaleidoscope program (an extension from the Frosted Pink initiative to include more women in the fold).

Personalized Cancer Care

Personalized Cancer Care

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New Evidence Suggests Link between Lung Cancer, Hormones in Women - ASCO

New Evidence Suggests Link between Lung Cancer, Hormones in Women - ASCO

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New Research Focuses on Benefits of Targeted Agents in the Treatment of Advanced Non-small Cell Lung Cancer - ASCO

New Research Focuses on Benefits of Targeted Agents in the Treatment of Advanced Non-small Cell Lung Cancer - ASCO

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